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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionISOPtgs2 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of PTGS2 mRNA; T-2 Toxin results in increased expression of PTGS2 proteinPMID:36115646 PMID:36775139
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]PMID:36775139
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