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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2multiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]PMID:15980035 PMID:18089846 PMID:23968725
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDwortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]PMID:18840457 PMID:22952890
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