GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of PTGS2; Arsenic Trioxide results in decreased expression of PTGS2 mRNA; Arsenic Trioxide results in decreased expression of PTGS2 protein | PMID:15547942 PMID:19236750 PMID:21540248 PMID:24312908 PMID:26966376 PMID:27318970 | PTGS2 | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of PTGS2; Arsenic Trioxide results in increased expression of PTGS2 mRNA; Arsenic Trioxide results in increased expression of PTGS2 protein | PMID:17530438 PMID:18588940 PMID:23649692 PMID:29396848 | PTGS2 | multiple interactions | EXP | | 6480464 | CTD | 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; [Arsenic Trioxide co-treated with Dexamethasone] results in decreased expression of PTGS2 protein; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of PTGS2 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Arsenic Trioxide results in decreased expression of and affects the localization of PTGS2 protein; CAT protein inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Celecoxib promotes the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; Cyclosporine inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 protein]; Potassium Iodide inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 mRNA]; Potassium Iodide inhibits the reaction [Arsenic Trioxide results in increased expression of PTGS2 protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of PTGS2] | PMID:18588940 PMID:21078540 PMID:21540248 PMID:23649692 PMID:24312908 PMID:27318970 PMID:29396848 | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of PTGS2 mRNA | PMID:31258454 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | [Genistein co-treated with Arsenic Trioxide] results in decreased expression of PTGS2 protein; Arsenic Trioxide promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] | PMID:20339114 PMID:21078540 | | ||||||||||||||||||||||
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