GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of PTGS2 mRNA; Glucose results in decreased expression of PTGS2 protein | PMID:21333731 PMID:31655124 | PTGS2 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of PTGS2 mRNA; Glucose results in increased expression of PTGS2 protein | PMID:14514642 PMID:19225232 PMID:19557821 PMID:20578705 PMID:21333731 PMID:38115276 | PTGS2 | multiple interactions | EXP | | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased expression of PTGS2 protein]]; [Oxygen deficiency co-treated with Glucose deficiency] inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 protein]; Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; huai qi huang inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Rosiglitazone inhibits the reaction [Glucose results in decreased expression of PTGS2 protein]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]; Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PTGS2 protein] | PMID:14514642 PMID:19225232 PMID:19557821 PMID:20578705 PMID:21333731 PMID:28400208 PMID:38115276 | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of PTGS2 mRNA; Glucose results in increased expression of PTGS2 protein | PMID:12888618 PMID:19861503 PMID:23770986 PMID:36462176 | PTGS2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of PTGS2 mRNA | PMID:17178593 | PTGS2 | multiple interactions | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | IL1RN protein inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; IL1RN protein inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 protein] | PMID:19861503 PMID:23770986 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | [Glucose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein; NFKB1 protein inhibits the reaction [SOD1 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein]]; SOD1 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein] | PMID:16395278 PMID:29753610 | | ||||||||||||||||||||||
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