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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTD[Choline deficiency co-treated with Amino Acids, Peptides, and Proteins] results in increased expression of PTGS2 proteinPMID:11872629
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in increased expression of PTGS2 protein; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of PTGS2 mRNA; NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in increased expression of PTGS2 protein]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PTGS2 mRNA]PMID:20697377 PMID:22915297 PMID:34416350
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