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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:88212
Term: lead(II) chloride
Definition: An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Chemical ID: MESH:C029891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1decreases expressionISOHmox1 (Mus musculus)6480464CTDlead chloride results in decreased expression of HMOX1 mRNAPMID:23503628
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDlead chloride results in increased expression of HMOX1 mRNAPMID:20402460 PMID:23916686
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased expression of HMOX1 protein; [zinc chloride co-treated with Sodium Selenite] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased expression of HMOX1 protein]; Sodium Selenite inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased expression of HMOX1 protein]PMID:36646412
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