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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDIndomethacin results in increased expression of HMOX1 mRNAPMID:29027214
HMOX1multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMOX1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMOX1 mRNAPMID:28628672
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDIndomethacin results in decreased expression of HMOX1 mRNAPMID:25972201 PMID:30580614
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDIndomethacin results in increased expression of HMOX1 mRNAPMID:25110317 PMID:29027214 PMID:36868495
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDIndomethacin inhibits the reaction [Zymosan results in increased expression of HMOX1 protein]PMID:11454666
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDGallic Acid analog inhibits the reaction [Indomethacin results in increased expression of and results in increased activity of HMOX1 protein]; Indomethacin results in increased expression of and results in increased activity of HMOX1 protein; paeonol inhibits the reaction [Indomethacin results in decreased expression of HMOX1 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in decreased expression of HMOX1 mRNA]PMID:23892052 PMID:25110317 PMID:30580614
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