GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HMOX1 | increases activity | EXP | | 6480464 | CTD | cobaltous chloride results in increased activity of HMOX1 protein | PMID:11232018 | HMOX1 | increases expression | EXP | | 6480464 | CTD | cobaltous chloride results in increased expression of HMOX1 mRNA; cobaltous chloride results in increased expression of HMOX1 protein | PMID:16309584 PMID:16859120 PMID:18344023 PMID:19320972 PMID:19376846 PMID:20186739 PMID:22202117 PMID:29966676 PMID:9224953 | HMOX1 | multiple interactions | EXP | | 6480464 | CTD | cobaltous chloride results in increased expression of and results in increased activity of HMOX1 protein; cobaltous chloride results in increased stability of and results in increased expression of HMOX1 mRNA; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; KEAP1 protein promotes the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA] | PMID:10814519 PMID:18178725 PMID:22202117 PMID:27297870 PMID:29966676 | HMOX1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | cobaltous chloride results in increased expression of HMOX1 mRNA | PMID:11043581 PMID:17169330 PMID:18691609 | HMOX1 | increases expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | [cobaltous chloride results in increased expression of HIF1A protein] which results in increased expression of HMOX1 protein; cobaltous chloride results in increased expression of HMOX1 mRNA; cobaltous chloride results in increased expression of HMOX1 protein | PMID:12819242 PMID:15821039 PMID:17002867 PMID:17706837 PMID:18331222 PMID:20384596 PMID:21054399 PMID:21296072 PMID:22349312 PMID:23694759 PMID:23978538 PMID:24386269 PMID:25820916 PMID:7626009 | HMOX1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with cobaltous chloride] affects the expression of HMOX1 mRNA; ARNT affects the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA] | PMID:11043581 PMID:18691609 | HMOX1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; cobaltous chloride promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA] | PMID:15821039 PMID:17002867 PMID:18635243 PMID:19278353 PMID:25820916 | | ||||||||||||||||||||||
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