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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)15090820RGDthioacetamide decreases expression of Hmox1 protein in rat liver 
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDThioacetamide results in decreased expression of HMOX1 mRNA; Thioacetamide results in decreased expression of HMOX1 proteinPMID:30295103 PMID:30526075 PMID:32718261
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDThioacetamide results in increased expression of HMOX1 mRNA; Thioacetamide results in increased expression of HMOX1 proteinPMID:15504458
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of HMOX1 mRNA; Thioacetamide results in increased expression of HMOX1 proteinPMID:15976192 PMID:16337175 PMID:19822164 PMID:23411599 PMID:34492290
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; pomegranate fruit rind inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Verapamil inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]PMID:30526075 PMID:32718261
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