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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1multiple interactionsEXP 6480464CTDbaicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]PMID:37354967
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDbaicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 proteinPMID:14563492
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDHemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]PMID:14563492
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