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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of HMOX1 mRNA; Carbon Tetrachloride results in increased expression of HMOX1 proteinPMID:32234387
HMOX1affects expressionISOHmox1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride affects the expression of HMOX1 mRNAPMID:32380060
HMOX1decreases expressionISOHmox1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of HMOX1 mRNA; Carbon Tetrachloride results in decreased expression of HMOX1 proteinPMID:25471833 PMID:29964319 PMID:37894611
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of HMOX1 mRNA; Carbon Tetrachloride results in decreased expression of HMOX1 proteinPMID:16239168 PMID:21055838 PMID:24293383 PMID:24975872 PMID:27241356
HMOX1increases activityISOHmox1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased activity of HMOX1 proteinPMID:16978757
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of HMOX1 mRNA; Carbon Tetrachloride results in increased expression of HMOX1 proteinPMID:15496496 PMID:17917259 PMID:18078705 PMID:18187930 PMID:19793341 PMID:21725986 PMID:27339419 PMID:27746196 PMID:31919559 PMID:32063085 PMID:32234387
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of HMOX1 mRNA; Carbon Tetrachloride results in increased expression of HMOX1 proteinPMID:12963497 PMID:14572336 PMID:15976192 PMID:16309569 PMID:16964402 PMID:16978757 PMID:17202758 PMID:17229879 PMID:17275847 PMID:28347707
HMOX1increases metabolic processingISOHmox1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased metabolism of HMOX1 proteinPMID:16978757
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 mRNA; [Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; AK-1 compound promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Carbon Tetrachloride affects the reaction [NFE2L2 protein affects the expression of HMOX1 protein]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; rossicaside B promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; salecan inhibits the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; sulforaphane inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; Tretinoin promotes the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]PMID:17917259 PMID:18038451 PMID:18187930 PMID:19793341 PMID:21725986 PMID:22902988 PMID:25471833 PMID:26443840 PMID:29964319 PMID:32063085 PMID:32234387 PMID:37894611
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[Carbon Tetrachloride co-treated with diallyl disulfide] results in increased expression of HMOX1 protein; [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein; [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; Carbon Tetrachloride results in increased expression of and results in increased activity of HMOX1 protein; cobaltiprotoporphyrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; IL11 protein promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; puerarin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 protein]; tin mesoporphyrin inhibits the reaction [Carbon Tetrachloride results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]PMID:12963497 PMID:16964402 PMID:17275847 PMID:21055838 PMID:24293383 PMID:24975872 PMID:27241356 PMID:28935427 PMID:31168027
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