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GENE - TERM ANNOTATION REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: GO:0060546
Term: negative regulation of necroptotic process
Definition: Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
Definition Source(s): GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8acts_upstream_of_or_withinISOMGI:1047989068941MGI PMID:22089168

PMID:22089168
CASP8acts_upstream_of_or_withinISOMGI:104798 or MGI:1336166 or MGI:21549529068941MGI PMID:21368763

PMID:21368763
CASP8acts_upstream_of_or_withinISOMGI:104798 or MGI:19215069068941MGI PMID:22037414

PMID:22037414
CASP8acts_upstream_of_or_withinISOMGI:21549529068941MGI PMID:21402742

PMID:21402742
CASP8involved_inIDA 150520179UniProt PMID:31827280

PMID:31827280
CASP8involved_inISSUniProtKB:O89110150520179UniProt GO_REF:0000024
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