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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11b3
Name: cytochrome P450, family 11, subfamily b, polypeptide 3
Acc ID: CHEBI:3347
Term: candesartan
Definition: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.
Chemical ID: MESH:C081643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b3decreases expressionEXP 6480464CTDcandesartan results in decreased expression of CYP11B2 mRNAPMID:18796534
Cyp11b3affects response to substanceISOCYP11B2 (Homo sapiens)6480464CTDCYP11B2 protein polymorphism affects the susceptibility to candesartanPMID:12065207
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