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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71016
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp8b1increases expressionISOCyp8b1 (Mus musculus)6480464CTDglyceryl 2-arachidonate results in increased expression of CYP8B1 mRNAPMID:28095641
Cyp8b1increases expressionISOCYP8B1 (Homo sapiens)6480464CTDglyceryl 2-arachidonate results in increased expression of CYP8B1 mRNAPMID:23894352
Cyp8b1multiple interactionsISOCyp8b1 (Mus musculus)6480464CTDCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]PMID:23894352
Cyp8b1multiple interactionsISOCYP8B1 (Homo sapiens)6480464CTDCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]PMID:23894352
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