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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnip3
Name: potassium voltage-gated channel interacting protein 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnip3multiple interactionsISOKCNIP3 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of KCNIP3 mRNA; Resveratrol inhibits the reaction [[SOD1 protein mutant form results in increased susceptibility to Thimerosal] which results in increased acetylation of and results in increased ubiquitination of KCNIP3 protein]; Resveratrol inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein]]PMID:23557933 PMID:30503815
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