GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | increases response to substance | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased susceptibility to retrorsine | PMID:24799337 PMID:32910235 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein; CYP3A4 protein results in increased metabolism of and results in increased activity of retrorsine; Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]; SLC22A1 protein promotes the reaction [CYP3A4 protein results in increased susceptibility to retrorsine] | PMID:19818743 PMID:24799337 | | ||||||||||||||||||||||
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