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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:5294
Term: Gelsemine
Definition: An indole alkaloid that has formula C20H22N2O2.
Chemical ID: MESH:C063230
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases response to substanceISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in decreased susceptibility to gelseminePMID:34627953
Cyp3a2increases metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased metabolism of gelseminePMID:34627953
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