GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | affects response to substance | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 gene polymorphism affects the susceptibility to Etoposide; CYP3A4 protein affects the susceptibility to Etoposide | PMID:12969965 PMID:17279585 | Cyp3a2 | decreases methylation | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in decreased methylation of Etoposide | PMID:8114683 | Cyp3a2 | increases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased expression of CYP3A4 mRNA | PMID:31542801 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide] | PMID:25455453 PMID:8114683 | | ||||||||||||||||||||||
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