GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | decreases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Troleandomycin results in decreased activity of CYP3A4 protein | PMID:11409940 PMID:11752104 PMID:12467917 PMID:15005856 PMID:15557344 PMID:15860655 PMID:16049126 PMID:16416302 PMID:2271712 | Cyp3a2 | increases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Troleandomycin results in increased activity of CYP3A4 protein | PMID:9512926 | Cyp3a2 | increases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Troleandomycin results in increased expression of CYP3A4 mRNA | PMID:18505790 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen; [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen; Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of triflumuron]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Troleandomycin promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Troleandomycin results in increased expression of and results in increased activity of CYP3A4 protein | PMID:11752104 PMID:12695342 PMID:14652237 PMID:15764719 PMID:16049126 PMID:16207822 PMID:16416302 PMID:1740010 PMID:18505790 PMID:19299527 PMID:19697924 PMID:20863320 PMID:31082524 PMID:9600717 | |
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