GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | affects metabolic processing | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein affects the metabolism of Dextromethorphan | PMID:15988119 | Cyp3a2 | decreases methylation | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in decreased methylation of Dextromethorphan | PMID:15383492 | Cyp3a2 | increases metabolic processing | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Dextromethorphan | PMID:16595712 PMID:17267297 | Cyp3a2 | increases oxidation | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased oxidation of Dextromethorphan | PMID:15383492 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] | PMID:19818743 | |
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