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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases activityISOCYP3A4 (Homo sapiens)6480464CTDcypermethrin results in decreased activity of CYP3A4 proteinPMID:18420780 PMID:22634058
Cyp3a2increases activityISOCYP3A4 (Homo sapiens)6480464CTDcypermethrin results in increased activity of CYP3A4 proteinPMID:22310298
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDcypermethrin results in increased expression of CYP3A4 mRNA; cypermethrin results in increased expression of CYP3A4 proteinPMID:15548381 PMID:22310298
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