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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of CYP3A4 mRNAPMID:19224547
Cyp3a2affects expressionISOCYP3A4 (Homo sapiens)6480464CTDCyclosporine affects the expression of CYP3A4 mRNAPMID:24973091
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of CyclosporinePMID:15286053 PMID:15450954 PMID:15964336 PMID:15964407 PMID:8114683
Cyp3a2decreases expressionISOCYP3A4 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of CYP3A4 mRNAPMID:20106945 PMID:27989131 PMID:30008028 PMID:32152650 PMID:32253466
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDCyclosporine results in increased expression of CYP3A4 mRNAPMID:12673034
Cyp3a2increases metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased metabolism of CyclosporinePMID:20599501
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA; Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; Cyclosporine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]PMID:19299527 PMID:32152650 PMID:8114683
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