GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | increases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Carbofuran results in increased activity of CYP3A4 protein | PMID:22310298 | Cyp3a2 | increases chemical synthesis | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased chemical synthesis of Carbofuran | PMID:24016712 | Cyp3a2 | increases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Carbofuran results in increased expression of CYP3A4 mRNA | PMID:22310298 | Cyp3a2 | increases hydroxylation | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased hydroxylation of Carbofuran | PMID:15560889 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran; Carbofuran promotes the reaction [CYP3A4 protein affects the metabolism of Testosterone]; Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran] | PMID:15560889 PMID:24016712 | | ||||||||||||||||||||||
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