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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:34157
Term: 14,15-EET
Definition: An EET obtained by formal epoxidation of the 14,15-double bond of arachidonic acid.
Chemical ID: MESH:C046782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases chemical synthesisISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acidPMID:12675279
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]PMID:12675279
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