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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:34027
Term: 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Definition: A diarylmethane that has formula C14H9Cl5.
Chemical ID: MESH:C016340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects expressionEXP 6480464CTDo,p'-DDT affects the expression of CYP3A2 mRNAPMID:17984292
Cyp3a2increases activityISOCYP3A4 (Homo sapiens)6480464CTDo,p'-DDT results in increased activity of CYP3A4 proteinPMID:17035600
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDo,p'-DDT results in increased expression of CYP3A4 mRNA; o,p'-DDT results in increased expression of CYP3A4 proteinPMID:15548381 PMID:15795092 PMID:17035600 PMID:21924250
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]PMID:15795092
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