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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:30879
Term: alcohol
Definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
Chemical ID: MESH:D000438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDAlcohols results in increased expression of CYP3A4 mRNA; Alcohols results in increased expression of CYP3A4 proteinPMID:24025710
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDAlcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA]; Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA]; ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein]PMID:24025710
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