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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP3A2 mRNAPMID:18796159 PMID:21215274
Cyp3a2affects expressionISOCYP3A4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of CYP3A4 mRNAPMID:22298810
Cyp3a2decreases expressionISOCYP3A4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP3A4 mRNAPMID:16985168 PMID:28571685 PMID:31536130
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP3A4 mRNAPMID:23669205
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]PMID:28571685 PMID:29162470
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