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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:27418
Term: 1,4-naphthoquinone
Definition: The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.
Chemical ID: MESH:C035342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases abundanceISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased abundance of 1,4-naphthoquinonePMID:16243959
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTD1,4-naphthoquinone results in increased expression of CYP3A4 mRNAPMID:18602459
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