GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases phosphorylation | EXP | | 6480464 | CTD | Paclitaxel results in decreased phosphorylation of MAPK1 protein | PMID:35662665 | Mapk1 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein] | PMID:35662665 | Mapk1 | decreases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in decreased activity of MAPK1 protein | PMID:19815708 | Mapk1 | decreases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in decreased phosphorylation of MAPK1 protein | PMID:23956100 | Mapk1 | increases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased activity of MAPK1 protein | PMID:16211241 PMID:20106947 | Mapk1 | increases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased phosphorylation of MAPK1 protein | PMID:12510025 PMID:18594523 | Mapk1 | increases phosphorylation | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | Paclitaxel results in increased phosphorylation of MAPK1 protein | PMID:11123339 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [PD168393 co-treated with Paclitaxel] results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Paclitaxel results in increased phosphorylation of and results in increased activity of MAPK1 protein; Paclitaxel results in increased phosphorylation of and results in increased expression of MAPK1 protein; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein] | PMID:15907805 PMID:16051289 PMID:16211241 PMID:16413505 PMID:16580691 PMID:18594523 PMID:20106947 | Mapk1 | multiple interactions | ISO | Mapk1 (Mus musculus) | 6480464 | CTD | CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein] | PMID:11123339 | | ||||||||||||||||||||||
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