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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTD[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; bisphenol A inhibits the reaction [[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]PMID:30707916
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Dihydrotestosterone results in increased activity of AR protein mutant form] which results in increased phosphorylation of MAPK1 protein; AR protein promotes the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 proteinPMID:15466214 PMID:18819937
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[cypermethrin results in decreased susceptibility to Dihydrotestosterone] which results in decreased phosphorylation of MAPK1 proteinPMID:30974244
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