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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
Acc ID: CHEBI:22984
Term: calcium atom
Definition: An alkaline earth metal atom that has formula Ca.
Chemical ID: MESH:D002118
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk1affects abundanceISOPdk1 (Mus musculus)6480464CTDPDK1 protein affects the abundance of CalciumPMID:28887310
Pdk1multiple interactionsISOPdk1 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester affects the reaction [PDK1 protein affects the abundance of Calcium]; [PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium; Adenosine Triphosphate promotes the reaction [PDK1 protein affects the abundance of Calcium]; PDK1 protein affects the reaction [Thapsigargin affects the abundance of Calcium]; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium]; tubacin affects the reaction [PDK1 protein affects the abundance of Calcium]; tubacin inhibits the reaction [PDK1 protein affects the reaction [Thapsigargin affects the abundance of Calcium]]PMID:28887310
Pdk1multiple interactionsISOPDK1 (Homo sapiens)6480464CTDPDK1 protein affects the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]PMID:28634229
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