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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of SREBF1 mRNAPMID:19162173 PMID:28520973
Srebf1affects expressionISOSrebf1 (Mus musculus)6480464CTDPhenobarbital affects the expression of SREBF1 mRNAPMID:23091169
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDPhenobarbital results in decreased expression of SREBF1 mRNAPMID:21768169
Srebf1decreases expressionISOSrebf1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of SREBF1 mRNAPMID:19482888
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]; Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]; NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]; NR1I3 mutant form inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]; Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]PMID:21768169
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]PMID:19482888
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