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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:79995
Term: GW 3965
Definition: A diarylmethane that has formula C33H31ClF3NO3.
Chemical ID: MESH:C473027
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1increases expressionEXP 6480464CTDGW 3965 results in increased expression of SREBF1 mRNAPMID:28315714
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDGW 3965 results in increased expression of SREBF1 mRNA; GW 3965 results in increased expression of SREBF1 proteinPMID:16107141 PMID:23651738 PMID:27598782 PMID:29702089 PMID:32123961
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[Bexarotene co-treated with GW 3965] results in increased expression of SREBF1 mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of SREBF1 mRNA; puag-haad inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]PMID:23651738 PMID:29702089 PMID:32123961
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTDGW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]PMID:31421115
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