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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:75045
Term: dabrafenib
Definition: An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Chemical ID: MESH:C561627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases cleavageISOSREBF1 (Homo sapiens)6480464CTDdabrafenib results in decreased cleavage of SREBF1 proteinPMID:29950559
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[BRAF protein affects the susceptibility to dabrafenib] which affects the cleavage of SREBF1 proteinPMID:29950559
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