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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDLovastatin results in increased expression of SREBF1 mRNAPMID:32739440
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNAPMID:29852127
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