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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases expressionEXP 6480464CTDClofibrate results in decreased expression of SREBF1 mRNAPMID:17522070
Srebf1decreases expressionISOSrebf1 (Mus musculus)6480464CTDClofibrate results in decreased expression of SREBF1 mRNAPMID:23811191
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDClofibrate results in increased expression of SREBF1 mRNAPMID:27089845
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SREBF1 mRNA]PMID:17585979
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