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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:166802
Term: 22-Hydroxycholesterol
Definition: null
Chemical ID: MESH:C003585
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1increases expressionISOSrebf1 (Mus musculus)6480464CTD22-hydroxycholesterol results in increased expression of SREBF1 mRNA; 22-hydroxycholesterol results in increased expression of SREBF1 proteinPMID:16763553
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [Arsenic Trioxide results in decreased expression of SREBF1 protein]PMID:27622732
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTD22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A1 promoter]; 22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A2 promoter]PMID:16763553
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