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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:44215
Term: NAD zwitterion
Definition: A NAD that has formula C21H27N7O14P2.
Chemical ID: MESH:D009243
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2affects bindingEXP 6480464CTDNAD binds to ALDH2 proteinPMID:15629893 PMID:21276780
Aldh2multiple interactionsEXP 6480464CTDMagnesium affects the reaction [NAD binds to ALDH2 protein]PMID:21276780
Aldh2affects abundanceISOAldh2 (Mus musculus)6480464CTDALDH2 gene polymorphism affects the abundance of NAD; ALDH2 protein affects the abundance of NADPMID:15900217
Aldh2affects bindingISOAldh2 (Mus musculus)6480464CTDALDH2 protein binds to NADPMID:15900217
Aldh2affects bindingISOALDH2 (Homo sapiens)6480464CTDALDH2 protein binds to NADPMID:23295226
Aldh2multiple interactionsISOALDH2 (Homo sapiens)6480464CTD[ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde; NAD inhibits the reaction [[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein]; NAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH2 protein]; NAD inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of ALDH2 protein]PMID:10559215 PMID:22339434 PMID:37142061
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