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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDUric Acid results in increased expression of TGFB1 mRNAPMID:27542954
Tgfb1increases secretionISOTGFB1 (Homo sapiens)6480464CTDUric Acid results in increased secretion of TGFB1 proteinPMID:27542954
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]PMID:27542954 PMID:36850003
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