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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68645
Species: Mus musculus
RGD Object: Gene
Symbol: Cldn5
Name: claudin 5
Acc ID: CHEBI:76172
Term: loxoprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Chemical ID: MESH:C040656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn5increases expressionISOCLDN5 (Homo sapiens)6480464CTDloxoprofen metabolite results in increased expression of CLDN5 protein; loxoprofen results in increased expression of CLDN5 mRNA; loxoprofen results in increased expression of CLDN5 proteinPMID:34506768
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