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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628649
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mc2r
Name: melanocortin 2 receptor
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mc2rincreases secretionEXP 6480464CTDMC2R protein results in increased secretion of CorticosteronePMID:18609294
Mc2rmultiple interactionsEXP 6480464CTDMC2R protein promotes the reaction [PRL protein results in increased secretion of Corticosterone]; PRL protein promotes the reaction [MC2R protein results in increased secretion of Corticosterone]PMID:18609294
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