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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:38845
Term: profenofos
Definition: An organophosphate insecticide that has formula C11H15BrClO3PS.
Chemical ID: MESH:C024273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISOCYP2B6 (Homo sapiens)6480464CTDprofenofos results in decreased activity of CYP2B6 proteinPMID:22310298
Cyp2b3increases expressionISOCYP2B6 (Homo sapiens)6480464CTDprofenofos results in increased expression of CYP2B6 mRNAPMID:22310298
Cyp2b3increases metabolic processingISOCYP2B6 (Homo sapiens)6480464CTDCYP2B6 protein results in increased metabolism of profenofosPMID:23415833
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenolPMID:23415833
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