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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4increases expressionEXP 6480464CTDTunicamycin results in increased expression of ATF4 mRNA; Tunicamycin results in increased expression of ATF4 proteinPMID:24291486 PMID:24892553 PMID:28844859 PMID:32740777
Atf4multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [Tunicamycin results in increased expression of SESN2 protein]; salubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein]PMID:28844859 PMID:32740777
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTDTunicamycin results in increased expression of ATF4 mRNA; Tunicamycin results in increased expression of ATF4 proteinPMID:14604972 PMID:22115781 PMID:22378314 PMID:23741617 PMID:24312631 PMID:27358234 PMID:28688763 PMID:28743512 PMID:29453283 PMID:30592132 PMID:32357311 PMID:36473502 PMID:36586010 PMID:36640941
Atf4increases expressionISOAtf4 (Mus musculus)6480464CTDTunicamycin results in increased expression of ATF4 mRNA; Tunicamycin results in increased expression of ATF4 proteinPMID:22001960 PMID:22959925 PMID:24648495 PMID:32578922 PMID:36030031
Atf4increases phosphorylationISOATF4 (Homo sapiens)6480464CTDTunicamycin results in increased phosphorylation of ATF4 proteinPMID:22959463
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTD2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [[Tunicamycin co-treated with APP protein modified form] results in increased expression of PSEN1 mRNA]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]; Quercetin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]PMID:22115781 PMID:23741617 PMID:36640941
Atf4multiple interactionsISOAtf4 (Mus musculus)6480464CTD1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of ATF4 mRNA; EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]; EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]PMID:22959925 PMID:24648495 PMID:29793971
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