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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9multiple interactionsEXP 6480464CTDalpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]PMID:31712109
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDalpha-Tocopherol analog results in increased cleavage of CASP9 proteinPMID:20686688
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP9 proteinPMID:21869839 PMID:36058301
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