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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621445
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf4
Name: KLF transcription factor 4
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf4decreases response to substanceISOKLF4 (Homo sapiens)6480464CTDKLF4 results in decreased susceptibility to FluorouracilPMID:21833590
Klf4increases expressionISOKLF4 (Homo sapiens)6480464CTDFluorouracil results in increased expression of KLF4 mRNAPMID:16557594 PMID:17039268
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