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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:8107
Term: phenytoin
Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Chemical ID: MESH:D010672
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases expressionEXP 6480464CTDPhenytoin results in increased expression of NR1I3 proteinPMID:18473823
Nr1i3increases activityISONR1I3 (Homo sapiens)6480464CTDPhenytoin results in increased activity of NR1I3 proteinPMID:15849716
Nr1i3increases localizationISONR1I3 (Homo sapiens)6480464CTDPhenytoin results in increased localization of NR1I3 proteinPMID:15123723
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]PMID:15123723 PMID:17041008 PMID:21924250
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA]PMID:15155833 PMID:16936065
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