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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases secretionISOMMP2 (Homo sapiens)6480464CTDFolic Acid results in increased secretion of MMP2 proteinPMID:21349824
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [sodium arsenite results in decreased expression of MMP2 protein]PMID:37682722
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MMP2 mRNA; [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP2 mRNA; Folic Acid inhibits the reaction [AGT protein results in increased expression of and results in increased activity of MMP2 protein]PMID:20548288 PMID:20938992 PMID:22206623 PMID:23439872 PMID:24386282
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