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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:78761
Term: ML-7
Definition: An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Chemical ID: MESH:C070571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[ML 7 co-treated with quinocetone] results in increased cleavage of CASP8 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP8 protein]PMID:26446980
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