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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620937
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mlh1
Name: mutL homolog 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlh1affects response to substanceISOMLH1 (Homo sapiens)6480464CTDMLH1 mRNA affects the susceptibility to Fluorouracil; MLH1 protein affects the susceptibility to FluorouracilPMID:18497967 PMID:18949393
Mlh1increases response to substanceISOMLH1 (Homo sapiens)6480464CTDMLH1 protein results in increased susceptibility to FluorouracilPMID:17914563
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