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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cadecreases response to substanceISOPIK3CA (Homo sapiens)6480464CTDSirolimus results in decreased susceptibility to PIK3CA proteinPMID:10373522
Pik3caincreases activityISOPIK3CA (Homo sapiens)6480464CTDSirolimus results in increased activity of PIK3CA proteinPMID:16227402
Pik3caincreases expressionISOPik3ca (Mus musculus)6480464CTDSirolimus results in increased expression of PIK3CA mRNAPMID:31522336
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTDSirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]; Wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]PMID:16227402 PMID:27542212
Pik3camultiple interactionsISOPik3ca (Mus musculus)6480464CTDSirolimus inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]PMID:31522336
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